I'm not sure if this helps, but I've been following the development since V20 and the latest releases were always problematic for me with Wineskin: sometimes gamplay got sluggish, and big black blocks appeared in the place of certain objects.
But the current GOG version (1.07) with the 1.07HF, the industrial.zip and the processed_tiles.rar patches applied, works very well with WS8Wine1.2.3 & XQuartz. My setup is Core i3, OS X 1.7.3, HD3000. Haven't seen any black blocks and gameplay is snappy. Thanks for your work!