One thing I keep grumbling about is that the hot spots for the mouse cursor are really really small. Even when there is a box defining the location of the hot spot, you have to click around repeatedly in a small box to find the tiny, tiny good spot.
I have several time happened upon tool tips that I had no idea were there because I just happened to hit a hot spot in an odd place. Even loading a saved game is an exercise in shotgun clicking in the area you know hides the hot spot.
Hopefully easy to fix, but it really should be fixed.